Replication studies: Bad copy
نویسندگان
چکیده
منابع مشابه
Replication studies considered harmful
Context: There is growing interest in establishing software engineering as an evidence-based discipline. To that end, replication is often used to gain confidence in empirical findings, as opposed to reproduction where the goal is showing the correctness, or validity of the published results. Objective: To consider what is required for a replication study to confirm the original experiment and ...
متن کاملCopy Number Studies in Noisy Samples
System noise was analyzed in 77 Affymetrix 6.0 samples from a previous clinical study of copy number variation (CNV). Twenty-three samples were classified as eligible for CNV detection, 29 samples as ineligible and 25 were classified as being of intermediate quality. New software ("noise-free-cnv") was developed to visualize the data and reduce system noise. Fresh DNA preparations were more lik...
متن کاملDNA copy-number control through inhibition of replication fork progression.
Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and developmental disorders. DNA replication is regulated primarily at the level of initiation and is under strict cell-cycle regulation. Importantly, DNA replication is highly influenced by developmental cues. In Drosophila, sp...
متن کاملSCORe: A Scalable One-Copy Serializable Partial Replication Protocol
In this article we present SCORe, a scalable one-copy serializable partial replication protocol. Di↵erently from any other literature proposal, SCORe jointly guarantees the following properties: (i) it is genuine, thus ensuring that only the replicas that maintain data accessed by a transaction are involved in its processing, and (ii) it guarantees that read operations always access consistent ...
متن کاملDNA replication stress restricts ribosomal DNA copy number
Ribosomal RNAs (rRNAs) in budding yeast are encoded by ~100-200 repeats of a 9.1kb sequence arranged in tandem on chromosome XII, the ribosomal DNA (rDNA) locus. Copy number of rDNA repeat units in eukaryotic cells is maintained far in excess of the requirement for ribosome biogenesis. Despite the importance of the repeats for both ribosomal and non-ribosomal functions, it is currently not know...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 2012
ISSN: 0028-0836,1476-4687
DOI: 10.1038/485298a